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Synthesis of Enantiopure Amino Acids and Amines — Concerted Use of a Biocatalyst and a Chemocatalyst

✍ Scribed by Ian Archer; Reuben Carr; Ian Fotheringham; Robert Speight; Nicholas J. Turner

Publisher
John Wiley and Sons
Year
2007
Weight
11 KB
Volume
38
Category
Article
ISSN
0931-7597

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✍ Bian Wu; Wiktor Szymanski; Piet Wietzes; Stefaan de Wildeman; Gerrit J. Poelaren 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 254 KB 👁 1 views

## Abstract The phenylalanine aminomutase (PAM) from __Taxus chinensis__ catalyses the conversion of α‐phenylalanine to β‐phenylalanine, an important step in the biosynthesis of the __N__‐benzoyl phenylisoserinoyl side‐chain of the anticancer drug taxol. Mechanistic studies on PAM have suggested th