Synthesis of Enantiomerically Pure (−)-Wine Lactone Based on a Palladium-Catalyzed Enantioselective Allylic Substitution

Efficient Palladium-Catalyzed Substituti

Efficient Palladium-Catalyzed Substitution in Enantiomerically Pure Allyl Carbonates – A Stereodivergent Access to β-Aryl-Substituted γ-Lactones and γ-Hydroxy Amides

✍ Manfred Braun; Claudia Unger; Kersten Opdenbusch 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 263 KB 👁 1 views

Allyl carbonates (Z)-8 and (E)-9 are available from the converted into (S)-γ-butyrolactone 13 in a three step sequence. When the same protocol is applied to the isomeric addition of the chiral alkenyllithium reagent 5b to aromatic aldehydes 6. When sujected to a palladium-catalyzed diesters 10 and 1

Synthesis of Enantiomerically Pure (−)-Wine Lactone Based on a Palladium-Catalyzed Enantioselective Allylic Substitution

✦ Synopsis