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Synthesis of enantiomerically pure cyclopropyl carbocyclic nucleosides

✍ Scribed by Yufen Zhao; Te-Fang Yang; Migyoung Lee; Byoung K. Chun; Jinfa Du; Raymond F. Schinazi; Doowon Lee; M.Gary Newton; Chung K. Chu

Publisher: Elsevier Science
Year: 1994
Tongue: French
Weight: 266 KB
Volume: 35
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)73511-8

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✦ Synopsis

A numberof carbocyclic nucbxides have been synthesized as poteutial chemotherapeutic agents.t.2 Among these, calbovk:, andcycl0but-W ase paltkukly intemstiog since they exhibitpotatt anti-HIV activities andcarbovhiscunuttlyutkkxguingpmclinicalstudies.

AlthoughAZLddCarxlddIarecunentlyavailabkfor theaeatmtntdAIDSandHnrinfection,theirtoxicitiesandsidee&ca,aswellrtstheemrgglceofthedrug resistant viral strains, limit their usefulness as anbemkral agent&7 l?terefure. it is critical to search for new and less toxic anti-HIV agents which are not cmssxesismnt with the existing drugs.

Aspanofourdrugdisc<wery~~faAIDSandhepatitis.wehave~ninterestcdinthesynthesis and biological evaluation ofcyclqmqyl awbocyclic n&eosMes. Recently, sevd Mmatulia havelqorted thesyttthe&ofcycloptupylnucleosWs.

Forexatq&Kataghincrl.* ~~cYc@mpY~~ugsof oxebocinanditsduivativta.Theyalsoqonedthecyclopmpylhaanut~

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