Taking advantage of the high functionality of an enantiopure protected syn-2R-amino-l,3,4-triol derivative, easily available on a multigram scale from Disoascorbic acid, several biologically active compounds have been synthesized such as the (2S,3R)-3-amino-2-hydroxydecanoic acid (AHDA), the N-termi
Synthesis of enantiomeric 9-(2′,3′,4′-trihydroxybutyl)adenine derivatives from l-ascorbic and d-isoascorbic acids
✍ Scribed by Andrzej E Wróblewski; Wiesława Karolczak
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- French
- Weight
- 210 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0040-4020
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✦ Synopsis
Ascorbic and D-isoascorbic acids were employed in syntheses of 9-(2 0 ,3 0 ,4 0 -trihydroxybutyl)adenines protected at 3 0 and 4 0 oxygens (all four enantiomers) and at 2 0 oxygen (2 0 S,3 0 R and 2 0 S,3 0 S enantiomers).
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