Synthesis of (±)-eicosa-cis-8,9-(11, 12- and 14, 15-)epoxy-cis-11, 14-(8, 14- and 8, 11-) dienoic acids and attempted bioconversion to prostaglandins
✍ Scribed by Sung-Kee Chung; A.I. Scott
- Publisher
- Elsevier Science
- Year
- 1974
- Tongue
- French
- Weight
- 123 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract A four step synthesis of [5,6‐^14^C]‐eicosa‐5,8,11‐triynoic acid (1) from [^14^C]‐labelled acetylene is described. [^14^C~2~]‐acetylene was converted to 5‐chloro‐[1,2‐^14^C]‐pentyne via reaction of its monolithium salt with 3‐bromo‐1‐chloropropane. The doubly labelled 5‐chloropentyne th
3Z,6E)-l-Bromododeca-3,6-diene, a common intermediate in the synthesis of labelled 12t linoleic acid and 14t arachidonic acid, was obtained from (E)-3-nonyl-l-ol, in four steps, via conventional functional manipulations. Cross-coupling of this bromododecadiene with the Grignard reagent of l-chloro-5
Isomeric cis-2, 9-bis(aminomethyl)-5,7,7,12,14,14-hexameth-in the Ni configuration, which is accompanied by a concomitant change of the macrocycle conformation from a yl-1,4,8,11-tetraazacyclotetradecanes (6a and 6b) and their octahedral (4) and square-planar nickel(II) complexes ( 5) folded to a p