Synthesis of (E)-2,3′,4,5′-tetramethoxy[2-11C]stilbene

✍ Scribed by Lutz Schweiger; Stuart Craib; Andrew Welch; Tim A. D. Smith

• Book ID: 102370646
• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: French
• Weight: 122 KB
• Volume: 50
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.1439

✦ Synopsis

Abstract

In this paper, we describe the radiosynthesis of the compound (E)‐2,3′,4,5′‐tetramethoxy[2‐^11^C]stilbene, a potential, universal tumour positron emission tomography imaging agent. The production of (E)‐2,3′,4,5′‐tetramethoxy[2‐^11^C]stilbene was carried out via ^11^C‐methylation of (E)‐2‐(hydroxy)‐3′,4,5′‐trimethoxystilbene by using [^11^C]methyl trifluoromethanesulfonate ([^11^C]methyl triflate). (E)‐2,3′,4,5′‐tetramethoxy[2‐^11^C]stilbene was obtained with a radiochemical purity greater than 95% in a 20 ± 2% decay‐corrected radiochemical yield, based upon [^11^C]carbon dioxide. Synthesis, purification and formulation were completed on an average of 30 min following the end of bombardment (EOB). The specific radioactivity obtained was 1.9 ± 0.6 GBq/µmol at EOB. Copyright © 2007 John Wiley & Sons, Ltd.