The coupling of racemic 1-tBoc-4-CF3-beta-lactams with various C-10 modified baccatins has resulted in CF3-taxoids with diastereoselectivities ranging from 9:1 to one single isomer. The observed high diastereoselectivity is ascribed to the highly efficient enantiomer-differentiation by the enantiopu
✦ LIBER ✦
Synthesis of Docetaxel and Butitaxel Analogues through Kinetic Resolution of Racemic β-Lactams with 7- O -Triethylsilylbaccatin III
✍ Scribed by Ge, Haibo; Spletstoser, Jared T.; Yang, Yan; Kayser, Margaret; Georg, Gunda I.
- Book ID
- 121822630
- Publisher
- American Chemical Society
- Year
- 2007
- Tongue
- English
- Weight
- 96 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0022-3263
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A series of highly potent second-generation taxoids bearing a 2-methylprop-1-enyl or a 2-methylpropyl group at C-3' with modifications at the C-2, C-10, and C-14 positions was synthesized through the coupling of racemic cis-beta-lactams with properly protected/modified baccatin and 14-OH-baccatin. A