Synthesis of disaccharide congeners of the Trichinella spiralis glycan and binding site mapping of two monoclonal antibodies
β Scribed by Zhang, Ping; Appleton, Judith; Ling, Chang-Chun; Bundle, David R
- Book ID
- 121750430
- Publisher
- NRC Research Press
- Year
- 2002
- Tongue
- French
- Weight
- 817 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0008-4042
- DOI
- 10.1139/v02-117
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Scheme 2. Synthesis of 2 a-c, e. Reagents and conditions: a) BF 3 β’Et 2 O, Et 3 SiH, CH 2 Cl 2 , 08C, 1 h; b) BF 3 β’Et 2 O, allylTMS, CH 2 Cl 2 , 258C, 2 h; c) CyMgCl or AdMgBr, 0 8C, 1 h; d) Mitsunobu conditions, 25 8C, 2 h; e) H 2 , Pd/C, EtOH, 1 atm, 25 8C, 24 h. Scheme 3. Attempted synthesis of
Two pentasaccharide analogues and a hexasaccharide fragment of the Brucella A antigen [----2)-alpha-D-Rhap4NFo-(1----]n have been prepared as their methyl glycosides. The pentasaccharide analogues each have two formamido groups replaced by hydroxyl groups. Protected derivatives of the three oligosac