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Synthesis of Dihydronaphthalenes via Aryne Diels—Alder Reactions: Scope and Diastereoselectivity.

✍ Scribed by Chris Dockendorff; Stefan Sahli; Madeline Olsen; Ludovic Milhau; Mark Lautens


Publisher
John Wiley and Sons
Year
2006
Weight
27 KB
Volume
37
Category
Article
ISSN
0931-7597

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Cis-9,10-dihydro-9,10-ethanoanthracene-11-12-dicarboxylic acid anhydride (1) was converted into its amic acid derivative by reaction with L-leucine. The cyclization reaction was carried out in situ using triethylamine to give the succinic imide-acid derivative (2). Compound (2) was converted to the