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Synthesis of diastereomerically and enantiomerically pure (3S,4S)-statine

✍ Scribed by Mulzer, Johann ;Büttelmann, Bernd ;Münch, Winfried

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
511 KB
Volume
1988
Category
Article
ISSN
0947-3440

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✦ Synopsis

Diastcrcomcrically and enantiomerically pure (3S,4S kstatinc (2). the non-prolcinogcnic amino acid of thc protease inhibitor pepstatin (1). has bccn prepared rrom ( R )-2,3-0-isopropylideneglywrddchyde (4) in nine steps and 13% overall yield.

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