✦ LIBER ✦
Synthesis of di- and tri-saccharides related to the polysaccharide from Streptococcus pneumoniae type 23 and a study of their inhibition in the precipitin reaction
✍ Scribed by Asim K. Ray; Usha B. Maddali; Abhijit Roy; Nirmolendu Roy
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 558 KB
- Volume
- 197
- Category
- Article
- ISSN
- 0008-6215
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✦ Synopsis
Syntheses of methyl 2-O-&I_-rhamnopyranosyl-PD-galactopyranoside (9), methyl 2-O-cr-L-rhamnopyranosyl-/3-D-galactopyranoside (l3), and methyl 4-O-/3-D-glucopyranosyl-2-O-a-L-rhamnopyranosyl-BD-galactopyranoside ( 16) in good yields are described. Both 13 and 16 significantly inhibit antigen-antibody precipitation in the S. pneumoniae Type 23 immune system. The results indicate that the rhamnosyl group in the side chain of the repeating unit of the antigen is a! and not /3 as reported previously, and that the trisaccharide related to 16 is the immunodominant group.