Synthesis of deuterium labelled cocaine and pseudococaine

✍ Scribed by J. F. Casale; A. H. Lewin; H. T. Raney; D. A. Cooper

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: French
• Weight: 312 KB
• Volume: 29
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580290311

✦ Synopsis

Abstract

Cocaine and pseudococaine were mass‐labelled with deuterium at various positions on the tropane ring. The synthetic procedures followed were adaptations of those previously published for the unlabelled compounds. The isotopic purity was greater than 95% for 2‐[^2^H]–, 4,4‐[^2^H~2~]‐, and 1,5,6,6,7,7‐[^2^H~6~]‐cocaine and 3‐ [^2^H]‐, 4,4‐[^2^H~2~]‐, and 1,5,6,6,7,7‐[^2^H~6~]‐pseudococaine, while that of 3‐[^2^H]‐cocaine exceeded 90%.