Synthesis of deuterium labelled benomyl and carbendazim residue standards

✍ Scribed by William T. Zimmerman

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: French
• Weight: 234 KB
• Volume: 43
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/1099-1344(200007)43:8<767::aid-jlcr360>3.0.co;2-i

✦ Synopsis

SUMMARY
Three environmental degradation products of benomyl possessing tetradeutero-ring substitutions were synthesized for use in quantitative analysis of trace residues. The common precursor, 1,2-phenylenediamine, was exhaustively deuterated (\iota) pon heating in acidic aqueous media. Further synthetic transfornations to 2 -aminobenzimidazole(4,5,6,7-{ }^{2} \mathrm{H}{4}), carbendazim (-4,5,6,7-{ }^{2} \mathrm{H}{4}), aid 3-butyl-1,3,5-triazino[1.2a]benzimidazole-2,4(1H,3H)-dione-6,7,8,9-2 ({ }^{2} \mathrm{H}_{4}) proceeded with complete retention of the ring substituted deuterium.