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Synthesis of deuterium-labeled 7-azanorobrnane and 2-azabicyclo [2.2.2]-octane derivatives

✍ Scribed by Alan P. Marchand; Robert W. Allen

Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
265 KB
Volume
18
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The syntheses of four specifically‐deuterated 2,3‐benzo‐7‐azanorbornane derivatives and three specifically‐deuterated 5,6‐benzo‐2‐azabicyclo[2.2.2]octane derivatives are described.

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The synthesis of deuterium labelled anal
The synthesis of deuterium labelled analogues of a novel antidiarrhoeal agent, 2-[ 3,3-diphenyl-3-(2-methyl-1,3,4-oxadiazol-5-yl) propyl] -2-azabicyclo[2,2,2] octane
✍ P. H. Buckley; J. P. Dickens; T. A. Harrow; R. Honeyman 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 French ⚖ 248 KB

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Synthesis of 7-azabicyclo[2.2.1]heptane
Synthesis of 7-azabicyclo[2.2.1]heptane derivatives by transformation of tropinone
✍ Elena Gómez-Sénchez; José Marco-Contelles 📂 Article 📅 2006 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 306 KB

## Abstract magnified image The bromination (CuBr~2~, AcOEt/CHCI~3~) plus Favorskii rearrangement (EtONa, EtOH) of __N__‐carbethoxytropinone (**4**), readily available from tropinone (**3**), affords mixtures of __exo__‐ and __endo__‐isomers of 2,7‐dicarbethoxy‐7‐azabicyclo[2.2.1]heptane (**1b**)