The total synthesis of oleandomycin
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Kuniaki Tatsuta; Takashi Ishiyama; Shuichi Tajima; Yoshihito Koguchi; Hiroki Gun
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Article
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1990
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Elsevier Science
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French
⚖ 258 KB
The key aglycone, oleandolide, has been synthesized by coupling two segments of Cl-C7 and C&C14 portions, which are enantiospecifically derived from methyl U-L-and Drhamnosides, respectively. Oleandomycin (1) is a medicinally important 14-membered-ring macrolide antibiotic. Herein we describe the fi