Synthesis of Deoxyribonucleic Acid as a Function of the Radiation Dose to the Liver in Partially Hepatectomized Rats
β Scribed by LOONEY, W. B.; PARDUE, M. L.; BANGHART, F. W.
- Book ID
- 109628196
- Publisher
- Nature Publishing Group
- Year
- 1963
- Tongue
- English
- Weight
- 208 KB
- Volume
- 198
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/198804a0
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The effect of regucalcin, a Ca(2+)-binding protein isolated from rat liver cytosol, on deoxyribonucleic acid (DNA) synthesis in the nuclei of regenerating rat liver was investigated. At 1 day after partial hepatectomy, the liver weight was increased about 50% of that of sham-operated rats, and it re
## Abstract The role of endogenous regucalcin in the regulation of deoxyribonucleic acid (DNA) synthesis activity in the nuclei of regenerating rat liver after partial hepatectomy was investigated. The addition of regucalcin (0.25 and 0.5 ΞΌM) in the reaction mixture caused a significant decrease in
Although increased plasma enzyme activities could be diagnostic for tissue damage, the mechanisms controlling cellular enzyme release remain poorly understood. We found a selective and drastic elevation of serum enzyme activities accompanying rat liver regeneration after partial hepatectomy (PH), ap