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Synthesis of d3-cerivastatin for use as internal standard in a LC/MS/MS method developed for quantitation of the drug in human serum

✍ Scribed by Bang-Chi Chen; Mark S. Bednarz; Huiping Zhang; Peng Guo; Mohammed Jemal; Jeffrey A. Robl; Scott A. Biller; Joseph E. Sundeen; Balu Balasubramanian; Joel C. Barrish

Publisher
John Wiley and Sons
Year
2006
Tongue
French
Weight
111 KB
Volume
49
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

d~3~‐Cerivastatin was synthesized as an internal standard for use in a LC/MS/MS method developed for the simultaneous quantitative determination of the drug in human serum. d~3~‐Cerivastatin was efficiently prepared on large scale from d~3~‐iodomethane using improved procedures. Copyright © 2006 John Wiley & Sons, Ltd.

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