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Synthesis of cyclopropane substrate analog for 3-isopropylmalate dehydrogenase and its mechanism-based inhibition

โœ Scribed by Akira Chiba; Tadashi Eguchi; Tairo Oshima; Katsumi Kakinuma


Book ID
108379286
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
576 KB
Volume
55
Category
Article
ISSN
0040-4020

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We report the newly successful synthesis of 3-thia-glutaryl-CoA and a partial synthesis of 4-nitrobutyryl-CoA, substrate analogs to glutaryl-CoA dehydrogenase (GCD), an enzyme utilized by mammals and by bacteria in the metabolism of the amino acids L-tryptophan, L-lysine, and L-hydroxylysine. Using