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Synthesis of cyclopentenyl carbanucleosides via palladium(0) catalysed reactions

✍ Scribed by H. Kapeller; C. Marschner; M. Weißenbacher; H. Grieng

Book ID
104208301
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
869 KB
Volume
54
Category
Article
ISSN
0040-4020

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✦ Synopsis

Methyl 4-acetoxycyclopent-2-enylmethylcarboxylate (2) and the corresponding carbonate 3 have been treated with sodium salts and aluminum amides of pyrimidines, purines and methyl IH-1,2,4-triazole-3-carboxylate with a catalyst formed from bis(dibenzylideneacetone)palladium(0) and triisopropyl phosphite to give the corresponding carbanucleosides in good to excellent yields. This method was also applied for a synthesis of carbovir (31).

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✍ Hongjian Tian; Hasrat Ali; Johan E van Lier 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 75 KB

A series of novel functionalized trisulfonated phthalocyanines were prepared in good to excellent yield using the monoiodo trisulfonated phthalocyanine as precursor for palladium-catalysed cross coupling reactions (Heck reaction and Buchwald amination).