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Synthesis of Cyclohexapeptides Containing Pro and Aib Residues.

✍ Scribed by Tatjana Jeremic; Anthony Linden; Heinz Heimgartner

Publisher
John Wiley and Sons
Year
2005
Weight
8 KB
Volume
36
Category
Article
ISSN
0931-7597

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Synthesis of Cyclohexapeptides Containin
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## Abstract Cyclization reactions on hexapeptides containing several __α__‐aminoisobutyric acid (=2‐amino‐2‐methylpropanoic acid; Aib) residues and the turn‐promoting glycine (Gly) and proline (Pro) residues were investigated. Eight linear hexapeptides were synthesized, and their cyclization was at

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## Abstract The 18‐membered Aib‐containing cyclohexapeptides, cyclo(‐Gly‐Aib‐Aib‐Gly‐Aib‐Phe‐) (**22**), cyclo(‐Gly‐Aib‐Phe(2Me)‐Gly‐Aib‐Aib‐) (**24a**), cyclo(‐Gly‐Phe(2Me)‐Aib‐Gly‐Aib‐Aib‐) (**24b**), and cyclo(‐Gly‐Phe(2Me)‐Aib‐Gly‐Aib‐Phe‐) (**25**), have efficiently been synthesized by solutio

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Crystal structures of diketopiperazines containing α-aminoisobutyric acid: Cyclo(Aib-Aib) and cyclo(Aib-L-Ile)
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## Abstract The crystal and molecular structures of two α‐aminoisobutyric acid (Aib)‐containing diketopiperazines, cyclo(Aib‐Aib) 1 and cyclo(Aib‐L‐Ile) **2**, are reported. Cyclo(Aib‐Aib) crystallizes in the space group P1 with __a__ = 5.649(3), __b__ = 5.865(2), __c__ = 8.363(1), α = 69.89(6), β