Synthesis of crobarbatine acetate. A macrocyclic pyrrolizidine alkaloid ester
β Scribed by Huang, Jamin; Meinwald, Jerrold
- Book ID
- 127089442
- Publisher
- American Chemical Society
- Year
- 1981
- Tongue
- English
- Weight
- 1006 KB
- Volume
- 103
- Category
- Article
- ISSN
- 0002-7863
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π SIMILAR VOLUMES
## Abstract 1,2βDidehydrocrotalanine (**2**) is the first synthetic macrocyclic pyrrolizidine alkaloid analogue to be studied by Xβray crystallography. The crystal structure was solved by multisolution direct methods and refined by fullβmatrix leastβsquares to __R__ = 0.036 for 693 reflections. The
T r i t i a t e d mono-and disenecioyl dehydroretronecine (3.3dimethyl -acryl i c acid esters o f 1 -hydroxymethyl-70-hydroxy-6,7dihydro-5H-pyrrol izine) ( I V and V) were prepared by acylation o f 9-H -dehydroretronecine (l-hydroxymethyl-7B-hydroxy-6.7dihydro-5H-pyrrolizine ( 111)). The synthesis o