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Synthesis of constrained 4-(phosphonomethyl)phenylalanine derivatives as hydrolytically stable analogs of O-phosphotyrosine

✍ Scribed by Wang-Qing Liu; François Carreaux; Hervé Meudal; Bernard P. Roques; Christiane Garbay-Jaureguiberry


Book ID
103404170
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
740 KB
Volume
52
Category
Article
ISSN
0040-4020

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Novel constrained L-phenylalanine derivatives incorporating a benzazepinone or an azepinone ring were synthesized in 13 and 8 steps, respectively, employing a key base-catalyzed intramolecular cyclization reaction. The product, 2, was comparable in potency in a VCAM/VLA-4 ELISA assay to the correspo