Synthesis of conformationally-restricted boropeptide thrombin inhibitors
β Scribed by Joseph Cacciola; John M. Fevig; Richard S. Alexander; David R. Brittelli; Charles A. Kettner; Robert M. Knabb; Patricia C. Weber
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 331 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0960-894X
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The use of conformationally restricted phospholipids 1 and 2 has been employed to understand the conformational preference of phospholipase A2 (PLA2) for substrate phospholipids. Inhibition of porcine pancreatic PLA2 with 1 and 2 indicated a two-to fivefold preference for the distal isomer 2 over th
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