Synthesis of Collagen-Like Sequential Polypeptides Containing O-Phospho-L-Hydroxyproline and Preparation of Electrospun Composite Fibers for Possible Dental Application
✍ Scribed by Kousaku Ohkawa; Shinya Hayashi; Naoto Kameyama; Hiroyuki Yamamoto; Mina Yamaguchi; Shigenari Kimoto; Shigeaki Kurata; Hisaaki Shinji
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 988 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1616-5187
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✦ Synopsis
Abstract
A synthetic route is described for collagen‐like polypeptides constructed from O‐phospho‐L‐hydroxyproline [Hyp(PO~3~H~2~)] residues. Using the synthetic polypeptides and a natural protein, gelatin, fine fibers and their network structures (ESNWs) were prepared via electrospinning. The composite ESNWs can induce the mineralization of calcium phosphate. The phosphoryl groups of the Hyp(PO~3~H~2~) residues affect both the crystalline phase and amount of the calcium phosphate, depending on the chemical structure in the repeating sequence. The composite ESNWs can be developed as a biocompatible replacement of the extracellular matrix of hard tissues, and thus can be applied as dental materials for restoration of dental cavities or as a sealant for pits and fissures.
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