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Synthesis of clozapine analogs and their affinity for clozapine and spiroperidol binding sites in rat brain

โœ Scribed by De Paulis, Tomas; Betts, C. Ross; Smith, Howard E.; Mobley, Philip L.; Manier, D. Hal; Sulser, Fridolin


Book ID
126231876
Publisher
American Chemical Society
Year
1981
Tongue
English
Weight
814 KB
Volume
24
Category
Article
ISSN
0022-2623

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Following up h e finQng that the non-imidazole drug clozapine shows a considerable histamine H3 receptor antagonistic activiryl 1.21 , a scrim of analogues and metabolites (clorapinc-N-oxide. and N-desmcthylclozapine) were tested for thcir affinity towards thc H3 receptor using the radiolabelled H,