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Synthesis of chiral β-methyl tryptamine-derived GnRH antagonists

✍ Scribed by Joseph P Simeone; Robert L Bugianesi; Mitree M Ponpipom; Mark T Goulet; Mark S Levorse; Ranjit C Desai

Book ID
104231345
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
65 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

The stereospecific formation of 2-aryl-b-methyl tryptamine derivatives 15 and 16 from chiral 4-chloro-1-(3,5dimethylphenyl)-3-methylbutanones is described. These intermediates were further manipulated into the GnRH antagonists 1b and 1c in five steps.

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