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Synthesis of chiral condensed S-heterocycles via stereoselective Michael-like addition to butenolides and α,ß-unsaturated lactams

✍ Scribed by Heike Faltz; Jörg Bohrisch; Wilko Wohlauf; Michael Pätzel; Peter G. Jones; Jürgen Liebscher


Book ID
103397005
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
623 KB
Volume
52
Category
Article
ISSN
0040-4020

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Michael addition of lithium benzylamide to the enantiomerically pure (S)-E-crotonyl complex of C(~5-C,H,)Fe(CO)(PPh~)l followed by trapping of the resultant enolate with methyl iodide or methanol occurs with high diastereoselectivity and gives after decomplexation the essentially optically pure (3R)