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Synthesis of chiral 3-substituted-3-aminomethyl-pyrrolidines and related compounds

โœ Scribed by Mark J. Suto; William R. Turner; Jeffrey W. Kampf


Book ID
112130459
Publisher
Journal of Heterocyclic Chemistry
Year
1992
Tongue
English
Weight
602 KB
Volume
29
Category
Article
ISSN
0022-152X

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Diastereoselective alkylation of N-acylnorbornene sultams 2 afforded a variety of enantiomerically pure products 3a-3e. Reduction with LiAlH 4 (LAH) followed by ditosylation furnished chiral 1,4-ditosylates 5a-5e which underwent a cyclization reaction with primary amines to afford chiral 1,3-and 1,3