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Synthesis of cationic cholesterol-containing amphiphiles with an acid-labile linker

โœ Scribed by Vadim N. Sokolik; Tatyana V. Sokolova; Mikhail A. Maslov; Nina G. Morozova; Galina A. Serebrennikova

Book ID
108209658
Publisher
Royal Society of Chemistry
Year
2007
Tongue
English
Weight
227 KB
Volume
17
Category
Article
ISSN
0959-9436

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Mild and efficient preparation of acid-labile resins with displaceable halide linkers (3 and 4, X = Br and 1) is described. These resins can be used in combinatorial organic synthesis of numerous drug-scaffold libraries, Their synthetic utility is exemplified by high yielding N-alkylations with stru