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Synthesis of carbohydrate conjugates. Chemical modification of monosaccharides via 2,4,6-trichloro-1,3,5-triazine

✍ Scribed by Michael J. Adam; Laurance D. Hall


Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
620 KB
Volume
144
Category
Article
ISSN
0008-6215

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✦ Synopsis


Several monosaccharides and organic residues, including alkyl, spin-label and organometallic groups, have been linked in various combinations through nitrogen, oxygen, or sulfur atoms by treatment with 2,4,6-trichloro-1,3,5triazine. *For a preliminary communication, see ref. 1.


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## Abstract (__Ξ±__‐Aminoalkyl)phosphonates have efficiently been synthesized by multicomponent reaction of aldehydes, amines, and triethyl phosphite in the presence of 2,4,6‐trichloro‐1,3,5‐triazine at room temperature. The products are formed in high yields (83–91%) within 0.5–1β€…h.