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Synthesis of Carbocyclic Hydantocidins via Regioselective and Diastereoselective Phosphine-Catalyzed [3 + 2]-Cycloadditions to 5-Methylenehydantoins

โœ Scribed by Pham, Tien Q.; Pyne, Stephen G.; Skelton, Brian W.; White, Allan H.


Book ID
111889402
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
217 KB
Volume
70
Category
Article
ISSN
0022-3263

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Regioselective and diastereoselective ph
โœ Tien Q Pham; Stephen G Pyne; Brian W Skelton; Allan H White ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 77 KB

The phosphine-catalysed [3+2] cycloaddition of 5-methylenehydantoins 1 with the ylides 2a and 2b gives spirocyclic products with reverse regioselectivities; the latter ylide gives optically active products.