The synthesis of four isomerically pure tluoro-carbocyclic adenosine and guanosine analogues is described. The 3S,4S-bis(r-butyldiphenylsilyloxymethyl)-2-fluoropentan-l-o~ derivatives 22, 23, 24 and 25 synthesised from enantiomerically pure 3S,4S-bis(t-butyldiphenylsilyloxymethyl)-cyclopentanone (18
β¦ LIBER β¦
Synthesis of Carbocyclic 2',3'-Dideoxy-2'-C-hydroxymethyl Nucleosides as Potential Inhibitors of HIV
β Scribed by Rosenquist, Asa; Kvarnstroem, Ingemar; Svensson, Stefan C. T.; Classon, Bjoern; Samuelsson, Bertil
- Book ID
- 127251627
- Publisher
- American Chemical Society
- Year
- 1994
- Tongue
- English
- Weight
- 529 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0022-3263
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## Synthesis of 4-Substituted Carbocyclic 2,3-Dideoxy-3-Chydroxymethyl Nucleoside Analogues as Potential Antiviral Agents. -Evaluation of the title compounds for their anti-HIV-1 activity and cytopathic effects reveals that they are inactive. -(WACHTMEISTER,