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Synthesis of carbamates of .alpha.-amino sulfonamides

✍ Scribed by Gilmore, W. Franklin; Lin, Horng-Jau


Book ID
120045626
Publisher
American Chemical Society
Year
1978
Tongue
English
Weight
412 KB
Volume
43
Category
Article
ISSN
0022-3263

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Solid phase synthesis of sulfonamides us
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A method for the synthesis of sulfonamides on a solid support by immobilizing amines through the nitrogen atom using a carbamate linkage is described.

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## Abstract Both aliphatic and aromatic amino sulfonamides such as mafenide (**1a**) were synthesized in good yields (80–86%) by direct electrochemical hydrogenation of the corresponding nitriles in an __undivided__ cell containing a Ni cathode, a Pt anode, and __Raney__ Ni as catalyst (__Tableβ€…1__