Synthesis of C-nucleosides via coupling of ribosyl fluoride with typical aromatic heterocycles bearing a TMS group

✍ Scribed by Masataka Yokoyama; Mitsuru Nomura; Takeshi Tanabe; Hideo Togo

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 487 KB
• Volume: 6
• Category: Article
• ISSN: 1042-7163
• DOI: 10.1002/hc.520060214

✦ Synopsis

The direct coupling reaction of mribosyl fluoride with typical 7-excessive aromatic heterocycles such as furan, thiophene, pyrrole, benzofuran, benzothiophene, and indole and their trimethybilyl derivatives was performed in the presence of boron trifluoride to afford the corresponding C-nucleosides in moderate to good yields.

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Dedicated with gratitude to Prof. Shigeru Oae on the occa-"To whom correspondence should be addressed.

sion of his seventy-fifth birthday.