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Synthesis of C-glycosylated amino acids by hetero-Diels–Alder addition of ethyl 2-nitrosoacrylate to exo-glycals

✍ Scribed by Zoe S. Massen; Vassiliki C. Sarli; Evdoxia Coutouli-Argyropoulou; John K. Gallos


Book ID
108080774
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
559 KB
Volume
346
Category
Article
ISSN
0008-6215

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The hetero-Diels–Alder addition of ethyl
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A new method for the stereoselective synthesis of nonproteinogenic a-amino acids has been developed, which involves hetero-Diels-Alder addition of ethyl 2-nitrosoacrylate to electron-rich alkenes, such as enol ethers, enamines and allylsilanes, and a further two or three step manipulation of the res

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