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Synthesis of C-4 and C-7 triazole analogs of zanamivir as multivalent sialic acid containing scaffolds

✍ Scribed by Yan Lu; Jacquelyn Gervay-Hague


Book ID
108080462
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
364 KB
Volume
342
Category
Article
ISSN
0008-6215

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## Abstract 2, 3‐__O__‐Cyclohexylidene‐L‐erythruronic acid **(6)** available in 83% yield from D‐ribonolactone **(7)**, was treated with phenvlmagnesium bromide to give the D‐ribo and L‐__lyxo__ derivatives **10** and **11** in high yields (__Scheme 1__ and __2__). The diastereoselectivity depended