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Synthesis of both enantiomers of C2 symmetric trans-2,5-bis(hydroxymethyl)pyrrolidine. Lipase mediated sequential kinetic resolutions

✍ Scribed by Mukund P. Sibi; JianLiang Lu

Publisher: Elsevier Science
Year: 1994
Tongue: French
Weight: 347 KB
Volume: 35
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)73281-3

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✦ Synopsis

Lipase mediated sequential kinetic resolution has been employed to give both enantiomers of hans-2,5-bis(hydroxye~yl)pyrrolidine in optically pure form. The effect of different parameters on the ec and yields in these resolutions are also reported.

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