✦ LIBER ✦
Synthesis of Bis[di(2-pyridyl)methyl]amine (BDPMA) by a Novel One-Pot Multi-Step Reductive Amination with Molecular Sieves and Zn/iPrOH
✍ Scribed by Michael Renz; Catherine Hemmert; Bernard Meunier
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 158 KB
- Volume
- 1998
- Category
- Article
- ISSN
- 1434-193X
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✦ Synopsis
Bis[di(2-pyridyl)
methyl]amine (BDPMA) has been syn-in the synthesis of BDPMA due to a disfavored equilibrium towards the imine formation and therefore long reaction thesized by refluxing di-2-pyridyl ketone and di-(2pyridyl)methylamine in isopropanol in the presence of times were required, involving side reactions. The presented method can be used on large-scales and tolerates aromatic molecular sieves and acetic acid and subsequent reduction with zinc dust. The established methods for reductive heterocycles as functional groups. amination, i.e. NaBH 3 CN, NaBH(OAc) 3 and NaBH 4 , failed