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Synthesis of bis-(2,3,4,6-tetra-O-acetyl-α-d-mannopyranosyl)-l-serinyl phosphate, as a prodrug of mannose-1-phosphate

✍ Scribed by Amira Khaled; Christine Gravier-Pelletier; Yves Le Merrer


Book ID
108284264
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
127 KB
Volume
18
Category
Article
ISSN
0957-4166

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An efficient method for the synthesis of 1,2-truns-glycosides, introduced by Hanessian and Banoub ', involves treatment of acetylated glycosyl halides with partially protected sugar derivatives in the presence of silver triflate (promoter) and 1,1,3,3\_tetramethylurea (proton acceptor). However, 1,