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Synthesis of biotinylated tumor-associated carbohydrate antigens for immunological studies

โœ Scribed by Jianglong Zhu; Qian Wan; Samuel J. Danishefsky


Book ID
108285328
Publisher
Elsevier Science
Year
2009
Tongue
French
Weight
201 KB
Volume
50
Category
Article
ISSN
0040-4039

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The synthesis of biologically relevant glycosylamino acids using a non-natural amino acid as the glycosyl acceptor is described. The glycosylation reaction of a monosaccharide tri-chloroacetimidate donor with Fmoc-L-hydroxynorleucine benzyl ester provided the a-Olinked product. Conversely, when the