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Synthesis of biologically active 4-benzyl-1(2H)-phthalazinones and 2-aryl-3(2H)-1-benzal-isoindolinones

✍ Scribed by Dr. A. H. Bedair; R. Q. Lamphon; S. A. El Ghazal

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
321 KB
Volume
329
Category
Article
ISSN
1615-4150

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✍ Milton J. Kornet; George Shackleford πŸ“‚ Article πŸ“… 1999 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 136 KB

## Abstract Microwave irradiation of 1(2__H__)‐phthalazinone with benzyl halides and potassium carbonate in dimethyl‐formamide afforded 2‐benzyl‐1(2__H__)phthalazinones in modest yields. These products were tested in mice and rats in maximal electroshock and pentylenetetrazole seizure models for an