Synthesis of bilin-1,19-diones and biladiene-ac-1,19-diones with c(10) adamantyl and tert-butyl groups

✍ Scribed by Ari K. Kar; David A. Lightner

• Publisher: Journal of Heterocyclic Chemistry
• Year: 1998
• Tongue: English
• Weight: 672 KB
• Volume: 35
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570350404

✦ Synopsis

Abstract

Bilirubin and biliverdin analogs bearing bulky adamantyl and tert‐butyl groups at the central C(10) position were synthesized and their structures were analyzed by nmr and ultraviolet‐visible spectroscopy and by molecular mechanics calculations, all of which collectively indicated a preference for helical conformations.