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Synthesis of Bile Acid 24-acyl Glucuronides

✍ Scribed by Junichi Goto; Naoaki Murao; Junji Oohashi; Shigeo Ikegawa


Book ID
117213909
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
183 KB
Volume
63
Category
Article
ISSN
0039-128X

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Glucuronidation of carboxylic acids, primarily catalyzed by hepatic UDPglucuronosyltransferases, is an important phase II metabolic pathway functioning in detoxification. Acyl glucuronides of 2-aryl propionates, however, can form covalently bound protein adducts, which may generate hypersensitive re