Inhibition of the rat hepatic microsomal
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Nariyasu Mano; Takaaki Goto; Ayako Nikaido; Takashi Narui; Junichi Goto
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Article
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2003
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John Wiley and Sons
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English
β 151 KB
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Glucuronidation of carboxylic acids, primarily catalyzed by hepatic UDPglucuronosyltransferases, is an important phase II metabolic pathway functioning in detoxification. Acyl glucuronides of 2-aryl propionates, however, can form covalently bound protein adducts, which may generate hypersensitive re