Synthesis of Bicyclic β-Sultams

✍ Scribed by Dr. Friedrich Cavagna; Dr. Wolfgang Koller; Dr. Adolf Linkies; Dr. Herbert Rehling; Dr. Dieter Reuschling

• Publisher: John Wiley and Sons
• Year: 1982
• Tongue: English
• Weight: 211 KB
• Volume: 21
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.198212010

✦ Synopsis

Of his 60th birthday

It is generally assumed that the biological activity Of E-lactam antibiotics depends on the reactivity of the 6-lactam ring. substitution of the CO-group of the 8-lactam by the S02-group leads to 6-sultams which are more reactive than corresponding 6-lactams / l / . We wish to report the synthesis of bicyclic 8-sultams structure is derived from that of penicillins.