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Synthesis of benzothiazole derivatives and their biological evaluation as anticancer agents

✍ Scribed by Rosanna Caputo, Maria Luisa Calabrò, Nicola Micale, Aaron D. Schimmer, Moshin Ali, Maria Zappalà, Silvana Grasso

Book ID
118777958
Publisher
Springer-Verlag
Year
2011
Tongue
English
Weight
322 KB
Volume
21
Category
Article
ISSN
1054-2523

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Based on 2-methyl-4-nitro-2H-pyrazole-3-carboxylic acid[2-(cyclohexanecarbonylamino)benzothiazol-6-yl]amide (1), which shows selective cytotoxicity against tumorigenic cell lines, 2,6-dichloro-N-[2-(cyclopropanecarbonylamino)benzothiazol-6yl]benzamide (13b) was designed and synthesized as a biologic