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Synthesis of benzopyrano[4,3-b](N-arylsulfonyl)indoles and benzopyrano[3,4-b](N-arylsulfonyl)indoles via intramolecular palladium-catalyzed aryl–aryl coupling reaction

✍ Scribed by Fan, Ling-ling; Che, Zhi-ping; Zhang, Rui; Yu, Xiang; Zhi, Xiao-yan; Xu, Hui


Book ID
113075704
Publisher
Springer
Year
2012
Tongue
English
Weight
314 KB
Volume
16
Category
Article
ISSN
1381-1991

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Various pyrimido[4,5-b] indoles and benzo [4,5]furo [2,3-d]pyrimidines were synthesized via a palladium-catalyzed intramolecular arylation of pyrimidine substrates. Thus, 4-aryloxy-or 4-anilino-5-iodopyrimidines were treated with Pd(OAc) 2 (PPh 3 ) 2 and base in DMF to give the regioselective cycli