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Synthesis of Aryl- and Heteroaryl[ a ]pyrrolo[3,4- c ]carbazoles

✍ Scribed by Sanchez-Martinez, Concha; Faul, Margaret M.; Shih, Chuan; Sullivan, Kevin A.; Grutsch, John L.; Cooper, Jeremy T.; Kolis, Stanley P.

Book ID: 126881835
Publisher: American Chemical Society
Year: 2003
Tongue: English
Weight: 129 KB
Volume: 68
Category: Article
ISSN: 0022-3263
DOI: 10.1021/jo034207x

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## Abstract For Abstract see ChemInform Abstract in Full Text.

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The synthesis of new analogues of Arcyriaflavin A in which one indole ring is replaced by an aryl or heteroaryl ring is described. These new series of aryl[a]pyrrolo[3,4-c]carbazoles were evaluated as inhibitors of Cyclin D1-CDK4. A potent and selective D1-CDK4 inhibitor, 7a (D1-CDK4 IC 50 =45 nM),

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