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Synthesis of aromatic nitriles by the metal-cyanide exchange reaction between aryl-lithium compounds and pentachlorobenzonitrile

✍ Scribed by N.J. Foulger; B.J. Wakefield

Publisher
Elsevier Science
Year
1972
Tongue
French
Weight
90 KB
Volume
13
Category
Article
ISSN
0040-4039

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✦ Synopsis

We have demonstrated1 that the addition of pentachlorophenyl-lithium to'aromatic n nitrilesL is reversible. We now report that if the adduct is approached from the other direction, i.e. by the reaction of an aryl-lithium compound with pentachlorobeneonitrile, pentachlorophenyl-lithium and the aromatic nitrile are formed: ArLi + C6Cl$zN + Ar\ ,c=NLi a=s ArCN + 'SC'5 C6C15Li

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## Abstract In the absence of catalysts, the three‐component, one‐pot synthesis of α‐amino nitriles proceeded using various aldehydes and ketones together with amines and trimethylsilyl cyanide (TMSCN) in high yields under neat conditions at room temperature. The addition order of the reagents had