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Synthesis of Antimalarial 1,2,4-Trioxanes via Photooxygenation of a Chiral Allylic Alcohol

โœ Scribed by Griesbeck, Axel G.; El-Idreesy, Tamer T.; Fiege, Maren; Brun, Reto


Book ID
125543370
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
61 KB
Volume
4
Category
Article
ISSN
1523-7060

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โœ Charles W. Jefford; Ernest C. McGoran; John Boukouvalas; Geoffrey Richardson; Br ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› John Wiley and Sons ๐ŸŒ German โš– 497 KB

The three dihydronaphtho[l,2,4]trioxines e l l have been synthesized and two of them converted to the five carbamate and ester derivatives 12-16 (Schemes I and 2). The resulting new trioxanes together with two already known and ascaridole (7) were tested for antimalarial activity against the sensiti