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Synthesis of anti-HIV nucleoside conjugates with lipophilic diol compounds

✍ Scribed by O. A. Tuchnaya; S. N. Elizarova; S. A. Sharikova; N. S. Shastina; A. E. Stepanov; A. M. Yurkevich; V. I. Shvets


Book ID
106491534
Publisher
Springer
Year
2006
Tongue
English
Weight
113 KB
Volume
40
Category
Article
ISSN
0091-150X

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Synthesis of isomeric nucleoside phospho
✍ Xiaoping Zheng; Vasu Nair πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 809 KB

Synthesis of cyclic analogs of the anti-HIV active acyclic nucleoside phosphonate, PMEA, is described. A key reaction in the synthesis was the stereoselective cyclization of an acyclic phosphonyl intermediate to a phosphonyltetrahydrofuran. Complete stereostructures of the target isomeric phosphony